Sep 26, 2022 · The main steps in the formation of bile are the uptake of bile acids and ions from plasma across the basolateral (sinusoidal) membrane, transport through the hepatocyte, and excretion via the canalicular membrane.

Bile formation is a unique function of the liver which is vital to survival of the organism. Knowledge of the mechanism of bile formation has progressed rapidly in recent years and has provided the basis for further diagnosis and treatment of cholestatic disorders.

Sep 12, 2022 · The Golgi apparatus, microtubules, and microfilaments in the hepatocytes participate in bile formation. The Golgi complex provides the vesicles for the substances secreted into the bile. The ATP-binding-cassette (ABC) that is newly synthesized is transferred from the Golgi complex to the canalicular membrane to function as a transporter.

Feb 28, 2024 · In this article, we shall consider the many different components of bile, and how these are produced in the liver. Bile is made up of bile acids, cholesterol, phospholipids, bile pigments (such as bilirubin and biliverdin), electrolytes and water.

Bile is an iso-osmotic electrolytic fluid that is formed in the liver and is a product of its secretory function. Bile is primarily secreted by hepatocytes (i.e., canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where it is modified by cholangiocytes (i.e., ductal bile).

The liver uses active transport to secrete bile salts into the canaliculus, the cleft between adjacent hepatocytes. Canalicular transport is the rate-limiting step in bile formation. Once secreted, bile salts draw other bile components (particularly sodium and water) into the canaliculus by osmosis.

Understand the physiologic functions of bile as a route for excretion and in aiding in the digestion and absorption of dietary lipids; Understand how bile acids are formed from cholesterol, how they are modified during gut passage, and their role in driving bile secretion

Canalicular bile is produced by polarized hepatocytes that hold transporters in their basolateral (sinusoidal) and apical (canalicular) plasma membrane. This review summarizes recent data on the molecular determinants of this primary bile formation.