The Buffalo Bills don’t have to worry about containing running back Joe Mixon or defensive end Jerry Hughes in their Week 5 clash with the Houston Texans, as the AFC South club has ruled both players out for this Sunday’s matchup on their final injury report of the week.

The Bills will look to bounce back after a losing effort against the Baltimore Ravens in Week 5, while the Texans (3-1) hope to further prove they belong at the top of the AFC. The Bills (3-1) are favored by just one point. The Texans will be a tough test for a Bills team that is decimated by injury on defense.

This year the Bills average seven more points per game (30.5) than the Texans give up (23.5). Buffalo collects 305.8 yards per game, 32 more yards than the 273.8 Houston allows. The Bills have two giveaways this season, while the Texans have three takeaways.

Houston Texans running back Joe Mixon is expected to miss a third consecutive game with an ankle injury, a person with knowledge of his status said. The Texans later ruled Mixon out in their injury report on Friday.

Another week, another matchup where the Houston Texans must trust the duo of Cam Akers and Dare Ogunbowale. Pro Bowl running back Joe Mixon is out for Week 5’s showdown against the Buffalo Bills, according to NFL Network’s Ian Rappaport.