Here, we explored how NMDARs signal in tLTD. We found that, regardless of frequency, L5 PC→PC tLTD relies on the non-ionotropic preNMDAR signaling pathway mediated by JNK2, which helps to resolve the ...

The brain really is an incredible organ, and neurons are the vital link between, well, everything. The brain is anything but ...

This means that the presynaptic neuron releases the neurotransmitter ... on the surface of a postsynaptic neuron 1. iGluRs are protein assemblies that, when binding to glutamate, open their ...

Whereas the postsynaptic antagonist actions of OPC-4392 are observed at much higher doses than those that elicit presynaptic agonism, these opposing effects occur at equivalent doses of OPC-14597.

Key evidence includes super-resolution microscopy showing colocalization of presynaptic (Bassoon) and postsynaptic (Homer1) markers; electron microscopy confirming the formation of synaptic ...

In our opinion, NMDA receptor-mediated postsynaptic LTP and kainate receptor-mediated presynaptic LTP in the ACC are important for chronic pain perception and injury-related anxiety, respectively.

A variety of antidotes have been reported to treat SSRI-induced sexual dysfunction effectively; however, virtually all the data on these agents are derived from open case reports and case series ...

Arsenal advanced to the Champions League semifinals for the first time since 2009 with a 5-1 aggregate victory over Real Madrid, beating the reigning champions 2-1 at the Santiago Bernabéu on ...

This page is now closed but a summary of the football match is available below, and you can go here for our full match report. Thanks for joining us at Al Jazeera Sport.