National Institutes of Health researchers have mapped how individual neurons in the primary somatosensory cortex receive brain-wide presynaptic ... biases shape movement neuron identity within ...

The activity of an individual neuron is constrained by the anatomical organization of its presynaptic network (the set of neurons from which it receives information). In the mouse brain ...

This applies in particular to the presynaptic part where neurotransmitter is released from synaptic vesicles, which in turn have to be recycled and refilled in a complex membrane trafficking cycle.

These connections make up the brain’s wiring diagram. Current methods for revealing this wiring ... For neurons to communicate, one neuron must produce a signal called a ligand. This ligand can then ...

and release is restricted to MB neurons that receive coincident stimulation. Our results indicate that postsynaptic activity can gate presynaptic dopamine release to regulate plasticity.

For example, given a train of presynaptic spikes, synapses may come to express short ... This model was also implemented using the NEURON simulation environment (Hines and Carnevale, 1997) and it ...