This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

A groundbreaking study led by researchers at Insilico Medicine has revealed the potential of TNIK inhibition as an innovative anti-aging strategy. Using an AI-driven robotics laboratory , the team ...

In addition, helicases are required for the replication of infectious viruses. Structural studies of small molecule inhibition of helicase action provide insight into their function as molecular ...

This joint trauma induces a presynaptic reflex inhibition of musculature surrounding the joint, termed arthrogenic muscle inhibition (AMI). The extent to which anterior cruciate ligament (ACL) injury ...

This applies in particular to the presynaptic part where neurotransmitter is released from synaptic vesicles, which in turn have to be recycled and refilled in a complex membrane trafficking cycle.

CS-associated modulation of DCN activity included a short-latency post-CS inhibition and long-latency excitations before and after the CS. The amplitudes of the post-CS responses correlated with the ...

Reducing the chloride concentrations in the axon and presynaptic terminals diminished the GtACR2 ... and provide a much-improved light-gated chloride channel for optogenetic inhibition. One way to ...