gut.bmj2d
Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer
Objective Cancer immunology is a growing field of research whose aim is to develop innovative therapies and diagnostic tests. Starting from the hypothesis that immune cells promptly respond to harmful ...
gut.bmj2d
Faecal metabolome and its determinants in inflammatory bowel disease
Objective Inflammatory bowel disease (IBD) is a multifactorial immune-mediated inflammatory disease of the intestine, comprising Crohn’s disease and ulcerative colitis. By characterising metabolites ...
gut.bmj2d
Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis
Objective Hepatic stellate cells (HSC) transdifferentiation into myofibroblasts is central to fibrogenesis. Epigenetic mechanisms, including histone and DNA methylation, play a key role in this ...
gut.bmj3d
Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat
Intestinal Disease Research Program, Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada M H Perdue, Intestinal Disease ...
gut.bmj4d
Irritable bowel syndrome: treatment based on pathophysiology and biomarkers
Objective To appraise the evidence that pathophysiological mechanisms and individualised treatment directed at those mechanisms provide an alternative approach to the treatment of patients with ...
gut.bmj4d
Microbiota-induced S100A11-RAGE axis underlies immune evasion in right-sided colon adenomas and is a therapeutic target to boost anti-PD1 efficacy
2 Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, China Background Tumourigenesis in right-sided and left-sided colons demonstrated ...
gut.bmj5d
Effect of endoscopic sleeve gastroplasty on gastric emptying, motility and hormones: a comparative prospective study
Correspondence to Dr Barham K Abu Dayyeh, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R), Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, ...
gut.bmj5d
Visceral hypersensitivity in non-erosive reflux disease
1 Neurogastroenterology Group, Centres for Academic Surgery, Institute of Cellular and Molecular Science, Barts and the London, Queen Mary’s School of Medicine and Dentistry, Whitechapel, London, UK 2 ...
gut.bmj6d
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets
1 Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, the Netherlands 2 Department of Experimental Internal Medicine, Academic Medical Centre, Amsterdam, the Netherlands ...
gut.bmj6d
Proton pump inhibitors affect the gut microbiome
1 University of Groningen and University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands 2 University of Groningen and University Medical Center ...
gut.bmj6d
Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease
a Department of Surgery, University of Heidelberg, Heidelberg, Germany, b Department of Immunochemistry, German Cancer Research Center, Heidelberg, Germany Dr B Sido, Department of Surgery, University ...
gut.bmj9d
Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus
Background Patients with type 2 diabetes mellitus (T2DM) have higher pancreatic cancer (PC) risk. While aspirin has chemopreventive effects on digestive cancers, its effect on PC among patients with ...