The San Francisco 49ers, along with their fans, are preparing for what is expected to be the hottest gametime temperature in ...

The 49ers must overcome not only temperatures in the 90s but do so against an Arizona team with offensive firepower.

What to look for from the top 49ers and Cardinals players and how to watch the game as they face off on Sunday, week 5.

The Arizona Cardinals got a significant injury boost Friday, as head coach Jonathan Gannon announced that tight end Trey ...

Preview the Week 5 matchup between the San Francisco 49ers and Arizona Cardinals with predictions, odds, over/under, spread, ...

The San Francisco 49ers (2-2) have 14 players listed on their injury report as they prepare to square off against the Arizona ...

Unsurprisingly, the 49ers lead the all-time series between these two teams. Surprisingly, they only lead 36-29 — a ...

Budda Baker will make his 100th career NFL start for the Arizona Cardinals on Sunday amid rumors he might be dealt before the ...

San Francisco 49ers general manager John Lynch spoke on Friday about the team's contingency plan in case Fred Warner is out ...

ARIZONA -- The Arizona Cardinals and San Francisco 49ers have released their final injury report of the Week 5 practice slate ...

Kyler Murray and the Arizona Cardinals (1-3) have not been consistent and are banged up on the offensive line, but they have ...

The San Francisco 49ers look for their first back-to-back wins of the season when they host the division rival Arizona ...