Linebacker Anfernee Jennings, who was questionable with a shoulder injury, has been officially ruled out for the Week 4 game.

SportsLine's model simulated New England Patriots vs. San Francisco 49ers 10,000 times and made its Week 4 NFL picks, ...

Not suiting up Sunday is safety Talanoa Hufanga who rolled his ankle in practice Thursday. Hufanga returned in Week 3 after ...

The Patriots look to reach .500 for the first time in years as they take on the 49ers in California. Follow along for live ...

San Francisco 49ers wide receiver Deebo Samuel (calf) is active for Sunday's Week 4 game against the New England Patriots.

Will the defense rebound in Week 4 against San Francisco? Plus updates on Drake Maye, Oshane Ximines and Cole Strange.

The 49ers face a must-win game in week 4 at home against an inconsistent young New England team. The Patriots believe they ...

The 49ers aim to reverse a disappointing start to the season Sunday afternoon when they host the New England Patriots at Levi ...

According to Ian Rapoport, rookie Drake Maye might have to wait a bit longer before starting for the Patriots.

How close is Drake Maye to starting for the Patriots? Albert Breer shares two factors in consideration for the team regarding ...

The New England Patriots and the San Francisco 49ers are both looking to rebound from a Week 3 loss and move their record to ...

San Francisco 49ers wide receiver Deebo Samuel (19) enters the field before an NFL football NFC divisional playoff game ...