A dangerous bird flu, in other words, was suddenly circulating in mammals—mammals with which people have ongoing, extensive ...

HA (Hemagglutinin) Binds to host cell receptors, mediates viral entry. Vaccine development, neutralizing antibody research, diagnostic reagents. NA (Neuraminidase) Cleaves sialic acid receptors to ...

Neuraminidase, an enzyme ... avoid basing universal vaccines on hemagglutinin's "head" to steer clear of a viral region associated with seasonal change. Within the genetic machinery of both ...

The article, entitled “Drug-Fc Conjugate CD388 targets influenza virus neuraminidase and is broadly protective ... and pandemic influenza with a single dose by directly inhibiting viral proliferation.

Mean 50% inhibitory concentration and standard deviation for CL and FL assays and minimal inhibitory concentration in HA assay against viral NA of a pandemic H1N1 influenza A virus and three ...

About CD388 CD388 is an investigational drug-Fc conjugate (DFC) comprised of multiple copies of a potent small molecule neuraminidase inhibitor stably ... with a single dose by directly inhibiting ...

Nov. 7, 2024 — Increased capabilities for genomic surveillance have offered new insights into global viral evolution ... unexplored 'dark side' of the neuraminidase (NA) protein ...

However, the N1/19 hybrid did generate antibodies that cross-inhibited N1/09 virus, so all four immunogens mSN1, N1/09, N1/09 hybrid and, N1/19 hybrid induced antibodies that could inhibit 2009 viral ...