The Week 1 opening lines were posted soon after the release ... The over/under is down a full point to 48.5. How do you read NFL Odds? NFL odds will begin with a plus or a minus sign.

Packers ML (+105) vs Eagles Titans +4 (-108) at Bears Bills -6.5 (-110) vs Cardinals Combined Odds: +653 If you place all three of these bets into a NFL Week 1 parlay bet, the odds would be +653.