America has highways, and then it has legends. Route 66 is firmly in the latter category, friends. The historic “Main Street ...

The Mother Road’s 300-mile journey across the Show-Me State delivers exactly what the state nickname promises—it shows you America as it once was, preserved like a perfectly maintained vintage ...

Southeast Missouri faces potential major flooding as rivers rise, with the Black, Current, St. Francis, and Mississippi rivers all projected to crest at various flood stages in the coming days.

Residents in Pacific, Missouri, are preparing for more flooding following Friday’s storms.Plans to fill sandbags, moves in ...

Grab your hiking boots, your furry besties, and their leashes for these amazing dog-friendly adventures in Missouri.

Elevation Oncology is ditching its sole clinical-stage asset in the wake of disappointing phase 1 data, leading the antibody-drug conjugate company to lay off 70% of its staff. The biotech had ...

Copyright 2025 The Associated Press. All Rights Reserved. Updated [hour]:[minute] [AMPM] [timezone], [monthFull] [day], [year] Follow AP’s full coverage of March ...

Earlier this week, a strong storm system brought heavy snow to high-elevation areas in California ... The strongest chance for tornados will be in southeastern Missouri, southwestern Illinois, western ...

NASHVILLE, Tenn. — No. 7-seeded Missouri basketball will open its postseason campaign against No. 10-seed Mississippi State in the second round of the SEC Tournament on Thursday at Bridgestone ...

A federal judge awarded the state of Missouri $24 billion in a lawsuit over China's alleged hoarding of personal protective equipment during the COVID-19 pandemic. Judge Stephen Limbaugh in the ...

The echoes of "Mr. Brightside" were replaced with a chorus of “Go Big Blue.” The Tigers’ frantic, late comeback attempt in their final game in Columbia had fallen short. No. 19/15-ranked ...

Defending state champion Chadwick is vying for a repeat in 2025. / Abigail Landwehr Special to the News-Leader / USA TODAY NETWORK Hearts will be broken, and dreams will become reality for a host ...