Here are our 25 favorite pairs of fictional best friends from movies and TV.

Kat Dennings tells PEOPLE why she asked Seann William Scott how to best say 'Dude, where's my car?' for the 'Shifting Gears' ...

Jennifer Coolidge says that working with Bill Murray for the first time was "scary as hell" with his violent turn in the dark ...

3."Rowan Atkinson as Mr. Bean. You know you've nailed a role when most of the world knows you as your character's name and ...

Unveiled in autumn 1965, the Ford Bronco came in three body styles, designated by the factory as U13, U14 and U15 but more ...

Illustration by Chloe Dowling for TIME (Source Images: Archive Photos—Stringer/, Columbia Pictures/Everett (2), ...