Joe Mixon has been out the last two weeks with a lingering ankle injury, and he's exepcted to miss a third straight game. Mixon suffered an ankle sprain in the

The Houston Texans will have to wait for their starting running back to return to action. According to Ian Rapaport of NFL Network, Joe Mixon has been ruled out for Sunday’s Week 5 game against the Bills. He’s also missed Weeks 3 and 4 after injuring his ankle in Week 2.

Houston Texans running back Joe Mixon is expected to miss a third consecutive game with an ankle injury, a person with knowledge of his status said. The Texans later ruled Mixon out in their injury report on Friday.