In this latest research in human brain tissue, using the tools of biochemistry and molecular biology, Karikari and team identified a core region of the tau protein that is necessary for NFT formation.

In this latest research, using the tools of biochemistry and molecular biology, Karikari and team identified a core region of the tau protein that is necessary for neurofibrillary tangle formation.

The fragments also directly compromise synapses they encounter along the way, according to a preprint posted February 24 on bioRxiv. Specifically, tau fragments containing the microtubule binding ...

STAs contain a core stretch of amino acids ... antibody recognizing the C-terminal of the microtubule-binding region, captures STAs. “I see no strong evidence that the assay measures tau assemblies,” ...