aDepartment of Medicine, Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada bMcMaster Center for Transfusion Research, McMaster University, Hamilton, ON L8N 3Z5, ...

all-trans retinol is considered to be a parent ... their activities by interacting with nuclear receptors (RARs [retinoic acid receptors] or RXRs [retinoic X receptors]) on cells and by activating ...

And in 2018, all-trans retinoic acid (ATRA), a vitamin A derivative, together with the injection of ATO, was approved by the Food and Drug Administration of the United States. How do ATRA and ATO ...

1 The patient was diagnosed as a case of APL (intermediate risk) and treated with a combination of all-trans-retinoic acid (45 mg/m 2 /day) and arsenic trioxide (0.15 mg/kg/day). Gum hypertrophy ...

However, not all retinoids are created equal ... It’s converted into retinoic acid, the active form of vitamin A, more ...

Acute promyelocytic leukaemia is a very aggressive form of leukaemia related to a characteristic acquired somatic mutation; it is highly curable when proper chemotherapy is associated to all-trans ...

Therefore, development of new effective drugs with fewer ARs is important. Recently, all-trans retinoic acid (ATRA), one of natural retinoids, has been reported to differentiate regulatory T cells and ...

Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest ...

1 Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan 2 Division of Radioisotope Research, Kyorin University School of Medicine, Tokyo, Japan Correspondence to Dr Hiroshi ...