The Lancet | The best science for better lives
WEBSep 20, 2024 · A high total dose of primaquine was highly efficacious in reducing recurrent P vivax parasitaemia in children compared with a low dose, particularly in children younger than 5 years. In children treated with high and intermediate daily primaquine doses compared with low daily doses, there was no increase in gastrointestinal symptoms or …
Antiviral effect of high-dose ivermectin in adults with COVID-19: A ...
WEBJun 17, 2021 · 45 participants were recruited (30 to IVM and 15 controls) between May 18 and September 9, 2020. There was no difference in viral load reduction between groups but a significant difference was found in patients with higher median plasma IVM levels (72% IQR 59–77) versus untreated controls (42% IQR 31–73) (p = 0·004).Mean ivermectin …
Chronic pain: an update on burden, best practices, and new …
WEBChronic pain exerts an enormous personal and economic burden, affecting more than 30% of people worldwide according to some studies. Unlike acute pain, which carries survival value, chronic pain might be best considered to be a disease, with treatment (eg, to be active despite the pain) and psychological (eg, pain acceptance and optimism as goals) …
The age of adolescence - The Lancet Child & Adolescent Health
WEBJan 17, 2018 · Adolescence is the phase of life stretching between childhood and adulthood, and its definition has long posed a conundrum. Adolescence encompasses elements of biological growth and major social role transitions, both of which have changed in the past century. Earlier puberty has accelerated the onset of adolescence in nearly …
Global Burden of Disease 2019 - The Lancet
WEBOct 15, 2020 · The latest global disease estimates, published in The Lancet, analyses 286 causes of death in 204 countries and territories to reveal the state of the world’s health just before the COVID-19 pandemic. The Global Burden of Disease Study provides a roadmap to where need is greatest, with country-specific data on risk factors and chronic disease …
Ageism: a social determinant of health that has come of age
WEBApr 10, 2021 · Ageism is an important social determinant of health that has been largely neglected until now. The social determinants of health are the non-medical factors that influence health outcomes and include the conditions in which people are born, grow up, and live and the wider set of forces and systems that shape the conditions of daily life. …
Pollution and health: a progress update - The Lancet
WEBMay 17, 2022 · The Lancet Commission on pollution and health reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. We have now updated this estimate using data from the Global Burden of Diseases, Injuriaes, and Risk Factors …
Acute respiratory distress syndrome: causes, pathophysiology, and ...
WEBOct 1, 2022 · Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be precipitated by a variety of causes. The pathophysiology of ARDS is complex and involves the activation and dysregulation of multiple overlapping and interacting pathways of …
For Authors: Submit your work - The Lancet
WEBSubmit your work. Once you are ready to submit your manuscript to The Lancet Group, please click on the submit button under the relevant journal title. This will take you through to the manuscript submission system where you will be able to upload your manuscript. Not quite ready yet?
Global prevalence and burden of depressive and anxiety disorders …
WEBNov 6, 2021 · This pandemic has created an increased urgency to strengthen mental health systems in most countries. Mitigation strategies could incorporate ways to promote mental wellbeing and target determinants of poor mental health and interventions to treat those with a mental disorder. Taking no action to address the burden of major depressive disorder …